nm 283 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T29094	Valopicitabine dihydrochloride	NMC283,Valopicitabine HCl,NM-283,Valopicitabine,NMC-283,Valopicitabine dihydrochloride, Valopicitabine HCl,NM283
	Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
T13281	Valopicitabine	NM283	HCV Protease
	Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic HCV infection.		HCV Protease
T13477	β-Glucuronidase-IN-1		Antibacterial
	β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuron...		Antibacterial
T12997	SR-318		p38 MAPK , TNF
	SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti-inflammatory activity.		p38 MAPK , TNF
T22272	Lifirafenib	BGB-283,Beigene-283	EGFR , Raf
	Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respective...		EGFR , Raf
T15767	LLY-283		Histone Methyltransferase
	LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.		Histone Methyltransferase
T13242	UbcH5c-IN-1		Others
	UbcH5c-IN-1 is a selective small-molecule Ubiquitin-conjugating enzyme UbcH5c inhibitor (Kd: 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85).		Others
T63817	Axl-IN-5
	Axl-IN-5 (compound 1) is an AXL inhibitor (IC50: 283 nM) that exhibits anticancer activity.
T79822	DGKα-IN-3
	DGKα-IN-3 (example 25), with an IC50 of 283 nM, is a selective DGKα inhibitor that augments anti-PD-1's anti-tumor activity by promoting T cell proliferation and function, showing promise for cancer and immunology resear...
T36427	PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)		PACAP
	Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expres...		PACAP
T35854	9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
	9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a r...
T15828	L 888607		Others
	L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).		Others